Nexgard is a monthly chewable flea and tick treatment for large dogs (25-50kg), killing fleas within hours and providing a full month of protection from a single palatable dose.
Composition: Each chewable tablet contains 136mg Afoxolaner, dosed at a minimum of 2.5mg/kg body weight.
Indications: Flea infestation; tick infestation; prevention of tick fever
Dosage: One chewable tablet once a month, matched to the dog's 25-50kg weight band. Weigh the dog accurately before administration.
Directions for use: Give with or after a meal. Most dogs accept it as a treat; watch for a few minutes to confirm the full tablet is swallowed.
How does the medicine work: Afoxolaner selectively inhibits GABA-gated and glutamate-gated chloride channels in the nervous systems of fleas and ticks, causing uncontrolled nerve activity and death, while having much lower affinity for the corresponding mammalian receptors.
Possible side effects: Isoxazoline-class drugs have been associated with neurologic adverse reactions such as tremors, ataxia and seizures - use with caution in dogs with a history of seizures. Safety in breeding, pregnant or lactating dogs has not been evaluated.
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